BVT-14225

BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 52 nM.

Product Specifications

CAS Number

[376638-65-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H320, H335

Target

11β-HSD

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/BVT-14225.html

Purity

98.23

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(N(CC)CC)CC1=CSC(NS(=O)(C2=CC=CC(Cl)=C2C)=O)=N1

Molecular Formula

C16H20ClN3O3S2

Molecular Weight

401.93

Precautions

H302, H315, H320, H335

References & Citations

[1]Barf T, et al. Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2002 Aug 29;45 (18) :3813-5.|[2]Vicker N, et al. Novel non-steroidal inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol. 2007 May;104 (3-5) :123-9.