N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide (Ac-IEPD-pNA) is a colorimetric peptide substrate of granzyme B that allows accurate measurement of granzyme B activity[1].
Product Specifications
CAS Number
216757-29-8
Product Name Alternative
Ac-IEPD-pNA
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Ser/Thr Protease
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-acetyl-ile-glu-pro-asp-p-nitroanilide.html
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC[C@H](C)[C@H](NC(C)=O)C(N[C@@H](CCC(O)=O)C(N1[C@@H](CCC1)C(N[C@@H](CC(O)=O)C(NC2=CC=C(C=C2)[N+]([O-])=O)=O)=O)=O)=O
Molecular Formula
C28H38N6O11
Molecular Weight
634.63
Precautions
H302, H315, H319, H335
References & Citations
[1]Kristina Fritsch, et al. Suppression of granzyme B activity and caspase-3 activation in leukaemia cells constitutively expressing the protease inhibitor 9. Ann Hematol. 2013 Dec;92 (12) :1603-9.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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