OXFBD04
OXFBD04 is a potent and selective BRD4 inhibitor with an IC50 of 166 nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity[1].
Product Specifications
CAS Number
[2231747-03-6]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oxfbd04.html
Concentration
10mM
Purity
98.99
Solubility
DMSO : ≥ 250 mg/mL
Smiles
OC(C1=CC(O)=CC(C2=C(C)ON=C2C)=C1)C3=CC=CN=C3
Molecular Formula
C17H16N2O3
Molecular Weight
296.32
References & Citations
[1]Jennings LE, et al. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorg Med Chem. 2018 Jul 15;26 (11) :2937-2957.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Available Sizes
Curated Selection
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