Oxcarbazepine

Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

Product Specifications

CAS Number

[28721-07-5]

Product Name Alternative

GP 47680

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Sodium Channel

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Oxcarbazepine.html

Purity

99.90

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1C2=CC=CC=C2CC(C3=CC=CC=C31)=O)N

Molecular Formula

C15H12N2O2

Molecular Weight

252.27

Precautions

H302

References & Citations

[1]Ashley M Thomas, et al. Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?J Pain. 2018 Jan;19 (1) :1-9.|[2]Ching-Yi Lee, et al. The effects of antiepileptic drugs on the growth of glioblastoma cell lines. J Neurooncol. 2016 May;127 (3) :445-53.|[3]M Schmutz, et al. Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action. Epilepsia. 1994;35 Suppl 5:S47-50.