PluriSIn #2
PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A) . PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs) [1].
Product Specifications
CAS Number
56563-17-8
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/plurisin-2.html
Purity
98.0
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C(N(C(N1)=O)C=C(F)C1=O)NC2=CC=CC=C2
Molecular Formula
C11H8FN3O3
Molecular Weight
249.20
References & Citations
[1]Uri Ben-David, et al. Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha. Stem Cells. 2015 Mar;33 (3) :1013-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
Available Sizes
Frequently Asked Questions
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