PluriSIn #2

PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A) . PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs) [1].

Product Specifications

CAS Number

[56563-17-8]

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/plurisin-2.html

Purity

98.0

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C(N(C(N1)=O)C=C(F)C1=O)NC2=CC=CC=C2

Molecular Formula

C11H8FN3O3

Molecular Weight

249.20

References & Citations

[1]Uri Ben-David, et al. Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha. Stem Cells. 2015 Mar;33 (3) :1013-9.