DB2313
DB2313 is a potent inhibitor of transcription factor PU.1. DB2313 inhibits PU.1-dependent reporter gene transactivation with an IC50 of 5 μM. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis in acute myeloid leukemia (AML) cells and has anticancer effects[1].
Product Specifications
CAS Number
2170606-74-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/db2313.html
Purity
99.48
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=C(COC2=CC=C(C3=NC4=CC=C(C(NC(C)C)=N)C=C4N3)C=C2)C=CC=C1COC5=CC=C(C6=NC7=CC=C(C(NC(C)C)=N)C=C7N6)C=C5
Molecular Formula
C42H41FN8O2
Molecular Weight
708.83
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF568 conjugate, 0.1mg/mL
![Hexachlorobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic Acid](https://cdn.genprice.uk/products/572/9133221748480/imageurl/trc-h290768-2.5g.webp)
Hexachlorobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic Acid
![CD19 Mouse Monoclonal Antibody [Clone ID: B-C3]](https://cdn.genprice.uk/products/937/68dd189d061270361e8fcf1e/imageurl/am31228bt-n.webp)
CD19 Mouse Monoclonal Antibody [Clone ID: B-C3]
