Elabela (19-32)

Elabela (19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ) . Elabela (19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela (19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1].

Product Specifications

CAS Number

[1886973-05-2]

UNSPSC

12352209

Target

Apelin Receptor (APJ) ; Arrestin

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/elabela-19-32.html

Purity

99.64

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1CCC(N1)=O)N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(N[C@@H](CCSC)C(N2[C@@H](CCC2)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CC=CC=C4)C(N5[C@@H](CCC5)C(O)=O)=O)=O)=O)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)=O

Molecular Formula

C75H119N25O17S2

Molecular Weight

1707.03

References & Citations

[1]Alexandre Murza, et al. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA That Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Apr 14;59 (7) :2962-72.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Citation 01

Cell Stress Chaperones. 2023 Jan;28 (1) :91-103.|J Cardiovasc Transl Res. 2022 Jun;15 (3) :535-547.|Mol Med. 2024 Nov 20;30 (1) :223.|Free Radic Biol Med. 2022 Mar:181:130-142.|Nat Commun. 2025 Jul 21;16 (1) :6682.