Lithocholic acid

Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist[1][2][3][4][5].

Product Specifications

CAS Number

[434-13-9]

Product Name Alternative

3α-Hydroxy-5β-cholanic acid

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Apoptosis; Autophagy; Endogenous Metabolite; FXR

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Lithocholic-acid.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 0.99 mg/mL (ultrasonic; warming; adjust pH to 11 with NaOH; heat to 60°C)

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](C[C@H](O)CC4)([H])CC3)C)([H])CC1

Molecular Formula

C24H40O3

Molecular Weight

376.57

Precautions

H315, H319, H335

References & Citations

[1]Jenkins, D.J., et al., Effect on blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol. N Engl J Med, 1993. 329 (1) : p. 21-6.|[2]Goldberg, A.A., et al., Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget, 2011. 2 (10) : p. 761-82.|[3]Matsubara, T., et al., TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res, 2012. 53 (12) : p. 2698-707.|[4]Yang R, et al. Metabolomic analysis of cholestatic liver damage in mice. Food Chem Toxicol. 2018 Jul 14;120:253-260.|[5]Yu J, et al. Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity. J Biol Chem. 2002 Aug 30;277 (35) :31441-7.