5-Ph-IAA-AM

5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA (HY-134653) analog which contains an acetoxymethyl (AM) group. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation[1][2][3].

Product Specifications

CAS Number

[2990123-10-7]

UNSPSC

12352005

Target

Histone Acetyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/5-ph-iaa-am.html

Concentration

10mM

Purity

99.04

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OCOC(C)=O)CC1=CNC2=C1C=C(C=C2)C3=CC=CC=C3

Molecular Formula

C19H17NO4

Molecular Weight

323.34

References & Citations

[1]Negishi T, et al. The auxin-inducible degron 2 (AID2) system enables controlled protein knockdown during embryogenesis and development in Caenorhabditis elegans. Genetics. 2022 Feb 4;220 (2) :iyab218. |[2]Goldner AN, et al. Evidence that tissue recoil in the early Drosophila embryo is a passive not active process[J]. Mol Biol Cell. 2023 Sep 1;34 (10) :br16.|[3]Eijlers P, et al. A nematode-specific ribonucleoprotein complex mediates interactions between the major nematode spliced leader snRNP and its target pre-mRNAs. Nucleic Acids Res. 2024 Jul 8;52 (12) :7245-7260.