5-Ph-IAA-AM
Product Specifications
UNSPSC Description
5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA (HY-134653) analog which contains an acetoxymethyl (AM) group. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation[1][2][3].
Target Antigen
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/5-ph-iaa-am.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCOC(C)=O)CC1=CNC2=C1C=C(C=C2)C3=CC=CC=C3
Molecular Weight
323.34
References & Citations
[1]Negishi T, et al. The auxin-inducible degron 2 (AID2) system enables controlled protein knockdown during embryogenesis and development in Caenorhabditis elegans. Genetics. 2022 Feb 4;220(2):iyab218. |[2]Goldner AN, et al. Evidence that tissue recoil in the early Drosophila embryo is a passive not active process[J]. Mol Biol Cell. 2023 Sep 1;34(10):br16.|[3]Eijlers P, et al. A nematode-specific ribonucleoprotein complex mediates interactions between the major nematode spliced leader snRNP and its target pre-mRNAs. Nucleic Acids Res. 2024 Jul 8;52(12):7245-7260.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-141894/5-Ph-IAA-AM-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-141894/5-Ph-IAA-AM-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2990123-10-7
Available Sizes
Curated Selection
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