Nudifloramide-d3
Nudifloramide-d3 (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly (ADP-ribose) polymerase (PARP-1) activity in vitro[1].
Product Specifications
CAS Number
1207384-48-2
UNSPSC
12352005
Target
Endogenous Metabolite; PARP
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Purity
99.47
Solubility
10 mM in DMSO|H2O : 33.33mg/mL (ultrasonic)
Smiles
C(N)(=O)C1=CN(C([2H])([2H])[2H])C(=O)C=C1
Molecular Formula
C7H5D3N2O2
Molecular Weight
155.17
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Rutkowski B, et al. N-methyl-2-pyridone-5-carboxamide: a novel uremic toxin? Kidney Int Suppl. 2003 May; (84) :S19-21.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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