Cutamesine dihydrochloride

Cutamesine (SA4503) dihydrochloride is a potent and selective sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Cutamesine dihydrochloride shows >100-fold less affinity for the sigma 2 receptor (IC50 of 1784 nM) . Cutamesine dihydrochloride has antidepressant effects[1][2].

Product Specifications

CAS Number

[165377-44-6]

Product Name Alternative

SA4503 (dihydrochloride) ; AGY94806 dihydrochloride

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/SA4503-dihydrochloride.html

Concentration

10mM

Purity

98.05

Solubility

DMSO : 30 mg/mL (ultrasonic; warming) |H2O : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1OC.Cl.Cl

Molecular Formula

C23H34Cl2N2O2

Molecular Weight

441.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Lever JR, et al. Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59 (6) :350-8.|[2]Tuerxun T, et al. SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. Neurosci Lett. 2010 Jan 29;469 (3) :303-8.|[3]Minabe Y, et al. Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study. Synapse. 1999 Aug;33 (2) :129-40.