Edrophonium (chloride)

Edrophonium chloride is a short-acting acetylcholinesterase (AChE) inhibitor. Edrophonium chloride has Ki values of 0.2, 0.2, and 0.4 μM and IC50 values of 0.2, 0.05, and 0.5 μM for AChE in human erythrocytes, purified calf forebrain, and purified octopus brain, respectively. Edrophonium chloride can be used to detect early digitalis toxicity and in the study of myasthenia gravis[1][2][3].

Product Specifications

CAS Number

[116-38-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Edrophonium-chloride.html

Concentration

10mM

Purity

99.39

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

C[N+](C)(CC)C1=CC=CC(O)=C1.[Cl-]

Molecular Formula

C10H16ClNO

Molecular Weight

201.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Pitt B, et al. Use of edrophonium chloride (tensilon) to detect early digitalis toxicity. Am J Cardiol. 1966 Oct;18 (4) :557-65.|[2]Boyle NA, et al. Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase. J Med Chem. 1997 Sep 12;40 (19) :3009-13.|[3]Yost CS, et al. Clinical concentrations of edrophonium enhance desensitization of the nicotinic acetylcholine receptor. Anesth Analg. 1994 Mar;78 (3) :520-6.