Recombinant Human SERPINH1

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

Hsp47

Gene Name

SERPINH1

UniProt

P50454

Cellular Locus

Endoplasmic reticulum lumen.

Reactivity

Human

Target Antigen

Serpin H1

Target

SERPINH1

Type

Protein

Applications

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Form

Liquid

Buffer

20 mM Tris

Function

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

Storage Conditions

Store at 4°C if entire vial will be used within 2-4 weeks. Store at or below - 20°C for longer periods of time. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long-term storage.

Specificity

SERPINH1

Formulation

Sterile-filtered colorless solution (1mg/ml) in 20mM Tris-HCl, pH 8.0, and 10% glycerol.

Buffer pH

pH 8.0

Target Background

SERPINH1 is a member of the serpin superfamily of serine proteinase inhibitors whose expression is induced by heat shock. As a molecular chaperone, it localizes to the endoplasmic reticulum lumen and binds collagen, thus participating in the maturation of collagen molecules, facilitating the folding and assembly of procollagen molecules, retaining unfolded molecules within the ER, and assisting in the transport of correctly folded molecules from the ER to the Golgi apparatus. Autoantibodies to SERPINH1 have been found in cases of rheumatoid arthritis.