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SCH 50911

SCH 50911, (+) - (S) -5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA (B) receptor antagonist, binds to GABA (B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA (B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM[1].

Product Specifications

CAS Number

733717-87-8

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sch-50911.html

Purity

98.0

Solubility

H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C[C@H]1CNC(C)(C)CO1

Molecular Formula

C8H15NO3

Molecular Weight

173.21

References & Citations

[1]Ong J, et al. The morpholino-acetic acid analogue Sch 50911 is a selective GABA (B) receptor antagonist in rat neocortical slices. Eur J Pharmacol. 1998 Nov 27;362 (1) :35-41.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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