Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp

Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1), and can be used for detection of proteinase 3 (PR3) activity[1][2].

Product Specifications

CAS Number

[1042405-14-0]

UNSPSC

12352209

Target

Amino Acid Derivatives

Type

Peptides

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/abz-val-ala-asp-nva-arg-asp-arg-gln-eddnp.html

Purity

99.49

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC(C1=CC=CC=C1N)=O)=O)=O)=O)CCC)=O)=O)=O)=O)NCCNC2=CC=C(C=C2[N+]([O-])=O)[N+]([O-])=O

Molecular Formula

C53H80N20O18

Molecular Weight

1285.33

References & Citations

[1]Yu J, et al. Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury. Redox Biol. 2024 Jun 6;74:103231. |[2]Korkmaz B, et al. Measurement of neutrophil elastase, proteinase 3, and cathepsin G activities using intramolecularly quenched fluorogenic substrates. Methods Mol Biol. 2012;844:125-38.