ALKBH1-IN-1
ALKBH1-IN-1 (Compound 13h) is a selective ALKBH1 inhibitor, with an IC50 of 0.026 μM and 1.39 μM in the fluorescence polarization and enzyme activity assay, respectively. ALKBH1-IN-1 can modulate the level of DNA 6mA modifications. ALKBH1-IN-1 can be used to study the functions of ALKBH1 and DNA 6mA[1].
Product Specifications
UNSPSC
12352005
Target
DNA Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alkbh1-in-1.html
Purity
98.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CN(C2=NC=C(OCC3=CC=CC(OC(F)(F)F)=C3)C=N2)N=C1)O
Molecular Formula
C16H11F3N4O4
Molecular Weight
380.28
References & Citations
[1]Xiong L, et al. Discovery of a Potent and Cell-Active Inhibitor of DNA 6mA Demethylase ALKBH1. J Am Chem Soc. 2024 Mar 13;146 (10) :6992-7006.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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