QX77

QX77 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells[1]. QX77 can impede self-renewal and promote differentiation of ES cells[2].

Product Specifications

CAS Number

1798331-92-6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/QX77.html

Purity

99.48

Solubility

DMSO : 15 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1)=O

Molecular Formula

C16H13ClN2O2

Molecular Weight

300.74

Precautions

H302, H315, H319, H335

References & Citations

[1]Jinzhong Zhang, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 Jun 23;292 (25) :10328-10346|[2]Yi Xu, et al. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020 Jul 24;369 (6502) :397-403.