QX77
QX77 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells[1]. QX77 can impede self-renewal and promote differentiation of ES cells[2].
Product Specifications
CAS Number
[1798331-92-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/QX77.html
Purity
99.48
Solubility
DMSO : 15 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1)=O
Molecular Formula
C16H13ClN2O2
Molecular Weight
300.74
Precautions
H302, H315, H319, H335
References & Citations
[1]Jinzhong Zhang, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 Jun 23;292 (25) :10328-10346|[2]Yi Xu, et al. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020 Jul 24;369 (6502) :397-403.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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