TA-316

TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells[1][2].

Product Specifications

CAS Number

[1429321-13-0]

Product Name Alternative

Megakaryocytes/platelets inducing agent

UNSPSC

12352005

Hazard Statement

H303, H315, H319, H335

Target

Cyclin G-associated Kinase (GAK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Megakaryocytes-platelets_inducing_agent.html

Purity

99.50

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C(C(NCC2=CC=C(C(NCCO)=O)C=C2)=O)S1)N/N=C(C3=CSC(C4=CC=C(Br)C=C4)=C3O)\C

Molecular Formula

C28H25BrN4O5S2

Molecular Weight

641.56

Precautions

H303, H315, H319, H335

References & Citations

[1]METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS.WO2013051625A1.|[2]Aihara A, et al. Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells. Blood Adv. 2017;1 (7) :468-476. Published 2017 Feb 28.