Human β-defensin-2

Human β-defensin-2 (HβD-2) is a small cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by a number of epithelial cells.Human β-defensin-2 has antimicrobial activity against gram-negative bacteria and Candida, but not gram-positive Staphylococcus aureus[1]. Human β-defensin-2 can be used for the study of colitis[2].

Product Specifications

CAS Number

[372146-20-8]

Product Name Alternative

HβD-2

UNSPSC

12352209

Target

Antibiotic; Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/human-β-defensin-2.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CC(O)=O)C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H]2NC3=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(NCC(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CSSC[C@@H](C(NCC(N[C@@H](CC(C)C)C(N4[C@@H](CCC4)C(NCC(N[C@@H]([C@H](O)C)C(N[C@H]3CCCCN)=O)=O)=O)=O)=O)=O)NC5=O)C(N[C@@H](CC6=CNC=N6)C(N7[C@@H](CCC7)C(N[C@@H](C(C)C)C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N9[C@@H](CCC9)C(O)=O)=O)=O)=O)NC2=O)C(N%10[C@@H](CCC%10)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%11=CC=C(C=C%11)O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@H]5[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

Molecular Formula

C188H305N55O50S6

Molecular Weight

4328.20

References & Citations

[1]J M Schröder, et al. Human beta-defensin-2. Int J Biochem Cell Biol|[2]Louis Koeninger, et al. Human β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis. Front Immunol. 2020 Jan 31;11:93.