Valanafusp alfa

Valanafusp alfa (AGT-181) is a chimeric monoclonal antibody that fuses human α-L-iduronidase (IDUA) and targets the human insulin receptor (HIR) . Valanafusp alfa has brain penetrating properties, making it useful for research on mucopolysaccharidosis type I (MPS I) [1].

Product Specifications

CAS Number

[1815583-32-4]

Product Name Alternative

AGT-181; HIRMAb-IDUA

UNSPSC

12352203

Target

Insulin Receptor

Type

Inhibitory Antibodies

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/valanafusp-alfa.html

Purity

98.42

Solubility

H2O

Smiles

[Valanafuspalfa]

Molecular Weight

(284.23 kDa)

References & Citations

[1]Boado RJ, et al. AGT-181: expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys. J Biotechnol. 2009 Oct 26;144 (2) :135-41.|[2]Boado RJ, et al. Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier. Biotechnol Bioeng. 2008 Feb 1;99 (2) :475-84.