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Carbetocin

Carbetocin, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM) . Carbetocin has the potential for postpartum hemorrhage research. Carbetocin can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS[1][2][3].

Product Specifications

CAS Number

37025-55-1

UNSPSC

12352209

Hazard Statement

H312+H332

Target

Oxytocin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Carbetocin.html

Purity

99.97

Solubility

DMSO : ≥ 31 mg/mL|H2O : ≥ 33.33 mg/mL

Smiles

O=C([C@H](CSCCCC(N[C@H](C1=O)CC2=CC=C(OC)C=C2)=O)NC([C@@H](NC([C@](NC([C@](N1)([H])[C@@H](C)CC)=O)([H])CCC(N)=O)=O)CC(N)=O)=O)N(CCC3)[C@@H]3C(N[C@@H](CC(C)C)C(NCC(N)=O)=O)=O

Molecular Formula

C45H69N11O12S

Molecular Weight

988.16

Precautions

H312+H332

References & Citations

[1]Stella Chaviaras, et al. Assessing the antidepressant-like effects of carbetocin, an oxytocin agonist, using a modification of the forced swimming test. Psychopharmacology (Berl) . 2010 May;210 (1) :35-43.|[2]Gerald Gimpl, et al. Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin. Eur J Pharmacol. 2005 Mar 7;510 (1-2) :9-16.|[3]David Feifel, et al. The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor gating. Eur Neuropsychopharmacol. 2012 May;22 (5) :374-8.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Scientific Category

Peptides

Clinical Information

Launched

Citation 01

Andrology. 2025 Sep 27.|Neuropharmacology. 2023 Sep 1:235:109576.

Available Sizes

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