Imirestat
Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.
Product Specifications
CAS Number
[89391-50-4]
Product Name Alternative
AL 1576; Alcon 1576; HOE 843
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/IMIRESTAT.html
Purity
99.59
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C1NC2(C(N1)=O)C3=C(C4=C2C=C(F)C=C4)C=CC(F)=C3
Molecular Formula
C15H8F2N2O2
Molecular Weight
286.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Carrington AL, et al. Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K (+) -adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats. Diabetologia. 1991 Jun;34 (6) :397-401.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Curated Selection
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