KRASG12D-IN-3
KRASG12D-IN-3 (compound Z1084) is an orally active KRASG12D inhibitor that inhibits the cell growth of AGS and AsPC-1 cells with IC50 values of 0.38 nM and 1.23 nM, respectively[1].
Product Specifications
CAS Number
[3033638-63-7]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/krasg12d-in-3.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(C(F)(F)F)C(C2=C(F)C(N=C(OC[C@]3(C/C(C4)=C(F)\F)N4CCC3)N=C5N(C[C@@H]6N[C@H]7CC6)[C@@H]7[C@H](C)O8)=C5C8=N2)=CC(N)=C1
Molecular Formula
C31H30ClF6N7O2
Molecular Weight
682.06
References & Citations
[1]Tao Jiang, et al. Pyrimidine-fused ring compound, and preparation method therefor and use thereof. WO2024061370A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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