KRASG12D-IN-3
KRASG12D-IN-3 (compound Z1084) is an orally active KRASG12D inhibitor that inhibits the cell growth of AGS and AsPC-1 cells with IC50 values of 0.38 nM and 1.23 nM, respectively[1].
Product Specifications
CAS Number
[3033638-63-7]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/krasg12d-in-3.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(C(F)(F)F)C(C2=C(F)C(N=C(OC[C@]3(C/C(C4)=C(F)\F)N4CCC3)N=C5N(C[C@@H]6N[C@H]7CC6)[C@@H]7[C@H](C)O8)=C5C8=N2)=CC(N)=C1
Molecular Formula
C31H30ClF6N7O2
Molecular Weight
682.06
References & Citations
[1]Tao Jiang, et al. Pyrimidine-fused ring compound, and preparation method therefor and use thereof. WO2024061370A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
043581 200 µL
UGT2B10, CT (UGT2B10, UDP-glucuronosyltransferase 2B10)
Sign In for Pricing
View Details 
NBP2-97835MFV450 0.1 mL
Rabbit Polyclonal PPP1R7 Antibody [mFluor Violet 450 SE]
Sign In for Pricing
View Details 
MBS2578576-01 0.025 mg
gsta1 Polyclonal Antibody (Capture/Detector)
Sign In for Pricing
View Details