PVZB1194
PVZB1194 is a biphenyl-type inhibitor of Kinesin-5 ATPase activity that binds to the α4/α6 site of the motor domain in a nucleotide competitive manner. PVZB1194 has an IC50 of 0.12 μM for KSP ATPase. PVZB1194 induces mitotic arrest with the formation of a monopolar spindle, and inhibits HeLa cells proliferatio (IC50: 5.5 μM) . PVZB1194 can be used in the study of tumors[1][2].
Product Specifications
CAS Number
[1141768-04-8]
UNSPSC
12352005
Target
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pvzb1194.html
Purity
99.64
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(C2=CC=C(C(F)(F)F)C(F)=C2)C=C1)(N)=O
Molecular Formula
C13H9F4NO2S
Molecular Weight
319.27
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Kinesin-5/Eg5/KSP
Available Sizes
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