ZLN024 (hydrochloride)
Product Specifications
UNSPSC Description
ZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 μM, 0.95 μM, 1.1 μM and 0.13 μM, respectively.
Target Antigen
AMPK
Type
Reference compound
Related Pathways
Epigenetics;PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ZLN024-hydrochloride.html
Solubility
DMSO : ≥ 46 mg/mL|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
CC1=CC=C(OCCSC2=NC=CC=N2)C(Br)=C1.[H]Cl
Molecular Weight
361.69
References & Citations
[1]Zhang LN, et al. Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One. 2013 Aug 20;8(8):e72092.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16708A/ZLN024-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16708A/ZLN024-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1883548-91-1
Available Sizes
Curated Selection
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