ZLN024 (hydrochloride)

ZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 μM, 0.95 μM, 1.1 μM and 0.13 μM, respectively.

Product Specifications

CAS Number

[1883548-91-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

AMPK

Type

Reference compound

Related Pathways

Epigenetics; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ZLN024-hydrochloride.html

Concentration

10mM

Purity

98.51

Solubility

DMSO : ≥ 46 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

CC1=CC=C(OCCSC2=NC=CC=N2)C(Br)=C1.[H]Cl

Molecular Formula

C13H14BrClN2OS

Molecular Weight

361.69

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Zhang LN, et al. Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One. 2013 Aug 20;8 (8) :e72092.