SJ988497

SJ988497 is a PROTAC JAK2 degrader. SJ988497 potently inhibits CRLF2-rearranged (CRLF2r) cell proliferation and degrades the CRBN neosubstrate GSPT1. SJ988497 consists of a Ruxolitinib (HY-50856) derivative, linker, and CRBN ligand Pomalidomide. SJ988497 can be used in the research of acute lymphoblastic leukemia (ALL) [1].

Product Specifications

CAS Number

[2595365-41-4]

UNSPSC

12352005

Target

JAK; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sj988497.html

Purity

99.03

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

CCCN1C=C(C=N1)C2=C3C=CNC3=NC(NC4=CC=C(C=C4)C(NCCCCNC5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O)=O)=N2

Molecular Formula

C36H36N10O5

Molecular Weight

688.74

References & Citations

[1]Chang Y, et al. Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia. Blood. 2021 Dec 9;138 (23) :2313-2326.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

JAK2

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

TP320758M 100 µg

GIMAP8 (NM_175571) Human Recombinant Protein

Ask

View Details

RC223789L3V 200 µL

VEGFA (NM_001025366) Human Tagged ORF Clone Lentiviral Particle

Ask

View Details

MG216274 10 µg

Cuedc2 (NM_024192) Mouse Tagged ORF Clone

Ask

View Details

NBP3-05865R 0.1 mL

Rabbit Polyclonal OCT1 Antibody [DyLight 550]

Ask

View Details