Pan KRas-IN-1
Pan KRas-IN-1 is a pan KRas inhibitor, can be used for agent resistance in cancer developed with KRas G12C inhibitors[1].
Product Specifications
CAS Number
[2791263-84-6]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-kras-in-1.html
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(C2=CC(O)=CC3=C2C(CC)=C(F)C=C3)N=CC4=C1N=C(N=C4N5C[C@](O)(CCC5)C)OC[C@@]67N(CCC7)C[C@@H](C6)F
Molecular Formula
C33H36F3N5O3
Molecular Weight
607.67
References & Citations
[1]Wang Xiaolun, et al. Preparation of azaquinazoline pan-KRas inhibitors: World Intellectual Property Organization, WO2022132200[P]. 2022-06-23.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
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