Rel-PROTAC PARP1 degrader
Rel-PROTAC PARP1 degrader is the relative configuration of ROTAC PARP1 degrader. ROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.
Product Specifications
UNSPSC
12352211
Target
PARP; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rel-protac-parp1-degrader.html
Purity
98.99
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
O=C(CN(C(N1C(C2=CC=C(OC)C=C2OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]1C4=CC=C(Cl)C=C4)=O)CC5)N5CC(NCCOCCOCCOCCOCCN6N=NC(C7=CC=C(N8N=C(C(C(N)=O)=CC=C9)C9=C8)C=C7)=C6)=O
Molecular Formula
C58H63Cl2N11O10
Molecular Weight
1145.09
References & Citations
[1]Zhao Q, et al. Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule. Chem Commun (Camb) . 2019 Jan 2;55 (3) :369-372.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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