α-Truxillic acid

α-Truxillic acid is form by the dimerization of two molecules of α-trans-cinnamic acid, with anti-inflammatory activities. α-Truxillic acid has no analgesic activity, but its derivatives bound to camphor fragments exhibit significant activity in the peripheral analgesic model (writhing test) [1][2].

Product Specifications

CAS Number

[490-20-0]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Drug Intermediate

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/alpha-truxillic-acid.html

Purity

99.93

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

OC([C@H]1[C@@H]([C@@H]([C@H]1C2=CC=CC=C2)C(O)=O)C3=CC=CC=C3)=O

Molecular Formula

C18H16O4

Molecular Weight

296.32

Precautions

H302, H312, H332

References & Citations

[1]Chi YM, et al. Antinociceptive activities of alpha-truxillic acid and beta-truxinic acid derivatives. Biol Pharm Bull. 2006 Mar;29 (3) :580-4.|[2]Sokolova A, et al. Synthesis and analgesic activity of new α-truxillic acid derivatives with monoterpenoid fragments[J]. Medicinal Chemistry Research, 2016, 25 (8) : 1608-1615.