DMA-135 (hydrochloride)
DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM) . DMA-135 hydrochloride has no significant toxicity in cell-based studies[1].
Product Specifications
CAS Number
2237925-62-9
UNSPSC
12352005
Target
Enterovirus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dma-135-hydrochloride.html
Purity
99.58
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NC(C#CC2=CC=CC=C2)=C(N(C)C)N=C1N)NC(N)=N.Cl
Molecular Formula
C16H18ClN7O
Molecular Weight
359.81
References & Citations
[1]Davila-Calderon J, et al. IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. Nat Commun. 2020;11 (1) :4775. Published 2020 Sep 22.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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