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Olmutinib (hydrochloride)

Olmutinib hydrochloride is an orally active and irreversible third EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain. Olmutinib hydrochloride is used for NSCLC[1][2].

Product Specifications

CAS Number

1842366-97-5

Product Name Alternative

HM61713 (hydrochloride) ; BI 1482694 (hydrochloride)

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/olmutinib-hydrochloride.html

Smiles

O=C(NC1=CC(OC2=NC(NC3=CC=C(N4CCN(CC4)C)C=C3)=NC5=C2SC=C5)=CC=C1)C=C.Cl.Cl

Molecular Formula

C26H28Cl2N6O2S

Molecular Weight

559.51

References & Citations

[1]Kim ES, et al. Olmutinib: First Global Approval. Drugs. 2016 Jul;76 (11) :1153-7.|[2]Mohamed W. Attwa, et al. Detection and characterization of olmutinib reactive metabolites by LC‐MS/MS: Elucidation of bioactivation pathways. Journal of Separation science. 18 November 2019.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

Frequently Asked Questions

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