(Rac) -PAT-494
(Rac) -PAT-494 is a type II autotaxin inhibitor with the activity of inhibiting the production of lysophosphatidic acid (LPA) in the blood. (Rac) -PAT-494 can participate in the inhibition of diseases related to cancer, fibrosis and inflammation by antagonizing the function of autotaxin. (Rac) -PAT-494 shows high activity in biochemical and plasma tests. (Rac) -PAT-494 can reduce plasma LPA levels after oral administration to rats[1].
Product Specifications
CAS Number
[1781233-72-4]
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rac-pat-494.html
Smiles
FC1=CC=C(CN2C3=CC=CC=C3C4=C2CN(C5C4)C(NC5=O)=O)C=C1
Molecular Formula
C20H16FN3O2
Molecular Weight
349.36
References & Citations
[1]Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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