Ch55

Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP) . Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research[1][2].

Product Specifications

CAS Number

[110368-33-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

RAR/RXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ch55.html

Purity

99.86

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=C(/C=C/C(C2=CC(C(C)(C)C)=CC(C(C)(C)C)=C2)=O)C=C1

Molecular Formula

C24H28O3

Molecular Weight

364.48

Precautions

H302, H315, H319

References & Citations

[1]Jetten AM, et al. New benzoic acid derivatives with retinoid activity: lack of direct correlation between biological activity and binding to cellular retinoic acid binding protein. Cancer Res. 1987 Jul 1;47 (13) :3523-7.|[2]Takahashi N, et al. Induction of differentiation and covalent binding to proteins by the synthetic retinoids Ch55 and Am80. Arch Biochem Biophys. 1994 Oct;314 (1) :82-9.