Cbl-b-IN-1

Cbl-b-IN-1 (Example 519) is an inhibitor of Cbl-b, with an IC50 of less than 100 nM. Cbl-b-IN-1 can promote the secretion of cytokines such as IL-2, IFN-γ, and TNF-α, facilitate T cell activation, and enhance the TCR signaling pathway. Cbl-b-IN-1 can be used in research on immunomodulation[1][2].

Product Specifications

CAS Number

[2368841-84-1]

UNSPSC

12352005

Target

E1/E2/E3 Enzyme; Interleukin Related

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cbl-b-in-1.html

Purity

99.66

Solubility

DMSO : 60 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=NC(C2CC2)=CC(CN(CC3)CC43CC4)=C1)NC5=CC=CC(C6(CC7=NN=CN7C)COC6)=C5

Molecular Formula

C29H34N6O2

Molecular Weight

498.62

References & Citations

[1]BARSANTI PAUL A (US), et al. INHIBITORS OF CBL-B AND METHODS OF USE THEREOF. WO/2019/148005A1.|[2]Wang J, et al. Cbl-b inhibition promotes less differentiated phenotypes of T cells with enhanced cytokine production. Cell Immunol. 2024 Sep-Oct;403-404:104863.