Cbl-b-IN-1
Cbl-b-IN-1 (Example 519) is an inhibitor of Cbl-b, with an IC50 of less than 100 nM. Cbl-b-IN-1 can promote the secretion of cytokines such as IL-2, IFN-γ, and TNF-α, facilitate T cell activation, and enhance the TCR signaling pathway. Cbl-b-IN-1 can be used in research on immunomodulation[1][2].
Product Specifications
CAS Number
[2368841-84-1]
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; Interleukin Related
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cbl-b-in-1.html
Purity
99.66
Solubility
DMSO : 60 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NC(C2CC2)=CC(CN(CC3)CC43CC4)=C1)NC5=CC=CC(C6(CC7=NN=CN7C)COC6)=C5
Molecular Formula
C29H34N6O2
Molecular Weight
498.62
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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