Trihexosylceramide (d18:1/12:0)

Trihexosylceramide (d18:1/12:0) is a type of Trihexosylceramide. In the renal tissue of heterozygous Fabry's disease, the cytoplasm of glomerular epithelial cells appears foamy. Trihexosylceramide accumulated in glomerular epithelial cells as identified by immunostaining[1][2].

Product Specifications

CAS Number

[474943-80-1]

UNSPSC

12352005

Hazard Statement

H225, H319

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/trihexosylceramide-d18-1-12-0.html

Purity

99.28

Solubility

THF : 0.2 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC(CCCCCCCCCCC)=O)CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO

Molecular Formula

C42H79NO13

Molecular Weight

806.08

Precautions

H225, H319

References & Citations

[1]Wang JR, et al. Improved sphingolipidomic approach based on ultra-high performance liquid chromatography and multiple mass spectrometries with application to cellular neurotoxicity. Anal Chem. 2014 Jun 17;86 (12) :5688-96. |[2]Fukushima M, et al. A female heterozygous patient with Fabry's disease with renal accumulation of trihexosylceramide detected with a monoclonal antibody. Am J Kidney Dis. 1995 Dec;26 (6) :952-5.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Curated Selection

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