Omtriptolide
Omtriptolide (PG490-88) is a derivative proagent of triptolide purified from the Chinese herb.
Product Specifications
CAS Number
195883-06-8
Product Name Alternative
PG 490-88
UNSPSC
12352005
Target
Apoptosis; IFNAR; Interleukin Related; NF-κB; TGF-β Receptor; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Omtriptolide.html
Purity
97.02
Solubility
H2O : 1.39 mg/mL (ultrasonic)
Smiles
C[C@@]([C@@]1([H])C[C@@H]2O3)(CCC4=C1COC4=O)[C@]5([C@H]([C@H]6[C@]7(C(C)C)O6)O5)[C@]23[C@@H]7OC(CCC(O)=O)=O
Molecular Formula
C24H28O9
Molecular Weight
460.47
References & Citations
[1]Kim HJ, et al. The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2014 Jun;349 (3) :518-25.|[2]Leonard CT, et al. PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft model. J Heart Lung Transplant. 2002 Dec;21 (12) :1314-8.|[3]Krishna G, et al. PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis. Am J Pathol. 2001 Mar;158 (3) :997-1004.|[4]Chen BJ, et al. Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion. Transplantation. 2000 Nov 27;70 (10) :1442-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK
Available Sizes
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