Omtriptolide

Omtriptolide (PG490-88) is a derivative proagent of triptolide purified from the Chinese herb.

Product Specifications

CAS Number

[195883-06-8]

Product Name Alternative

PG 490-88

UNSPSC

12352005

Target

Apoptosis; IFNAR; Interleukin Related; NF-κB; TGF-β Receptor; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; NF-κB; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Omtriptolide.html

Purity

97.02

Solubility

H2O : 1.39 mg/mL (ultrasonic)

Smiles

C[C@@]([C@@]1([H])C[C@@H]2O3)(CCC4=C1COC4=O)[C@]5([C@H]([C@H]6[C@]7(C(C)C)O6)O5)[C@]23[C@@H]7OC(CCC(O)=O)=O

Molecular Formula

C24H28O9

Molecular Weight

460.47

References & Citations

[1]Kim HJ, et al. The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2014 Jun;349 (3) :518-25.|[2]Leonard CT, et al. PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft model. J Heart Lung Transplant. 2002 Dec;21 (12) :1314-8.|[3]Krishna G, et al. PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis. Am J Pathol. 2001 Mar;158 (3) :997-1004.|[4]Chen BJ, et al. Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion. Transplantation. 2000 Nov 27;70 (10) :1442-7.