CA IX-IN-2

CA IX-IN-2 (Compound 9o) is an inhibitor for carbonic anhydrase (CA), that inhibits CA IX, CA XII and CA II with an IC50 of 5.6, 7.4 and 430 nM, respectively. CA IX-IN-2 inhibits the proliferation of cancer cell HCT-116, SW480, MDA-MB 231 and MCF-7, with IC50s of 14.63-29.33 μM. CA IX-IN-2 intercalates DNA, arrests cell cycle at G1/S phase, and induces apoptosis in MDA-MB-231. CA IX-IN-2 affects the mitochondrial membrane potential (MMP), increases the intracellular ROS levels, causes mitochondrial damage, and inhibits the cell migration of MDA-MB-231. CA IX-IN-2 exhibits antitumor efficacy in mouse models[1].

Product Specifications

CAS Number

[3009842-92-3]

UNSPSC

12352005

Target

Apoptosis; Carbonic Anhydrase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ca-ix-in-2.html

Smiles

O=C(C1=CC=C(C2=CC=CC(C3=O)=C12)N4CCN(CC4)CC(NC5=CC=C(C=C5)S(N)(=O)=O)=O)N3CCN(CC)CC

Molecular Formula

C30H36N6O5S

Molecular Weight

592.71

References & Citations

[1]Liang Q, et al., Discovery of novel 1,8-naphthalimide piperazinamide based benzenesulfonamides derivatives as potent carbonic anhydrase IX inhibitors and ferroptosis inducers for the treatment of triple-negative breast cancer. Bioorg Chem. 2024 Sep;150:107596.