VH032-OH
VH032-OH is the VH032-based VHL ligand. VH032-OH can be connected to the ligand for protein by a linker to form PROTACs[1].
Product Specifications
CAS Number
[2244684-42-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vh032-oh.html
Purity
99.43
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N(C[C@@H]1O)[C@@H](C1)C(NCC(C=CC(C(SC=N2)=C2C)=C3)=C3O)=O)[C@H](C(C)(C)C)NC(C)=O
Molecular Formula
C24H32N4O5S
Molecular Weight
488.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017;8 (1) :830. Published 2017 Oct 10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
Curated Selection
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