RR-11055

RR-11055 (Compound 8) is a ligand for E3 ligase, that exhibits an affinity with cereblon with Ki of 0.38 μM. RR-11055 can be used for synthesis of PROTAC Degrader ERD-1233 (HY-169367) [1].

Product Specifications

CAS Number

[3026009-09-3]

UNSPSC

12352005

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rr-11055.html

Smiles

O=C1C2=CC=C(N3[C@@](CNCC3)([H])CO4)C4=C2CN1[C@@H]5C(NC(CC5)=O)=O

Molecular Formula

C18H20N4O4

Molecular Weight

356.38

References & Citations

[1]Acharyya RK, et al., Discovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer. J Med Chem. 2024 Nov 14;67 (21) :19010-19037.