EGFR-IN-78
Product Specifications
UNSPSC Description
EGFR-IN-78 (compound A5)，a 2-aminopyrimidine derivative，is a reversible inhibitor of EGFRC797S-TK，and also an inducer of apoptosis. EGFR-IN-78 shows anti-proliferative activity，inhibits EGFR phosphorylation and arrests cell cycle at G2/M phase[1].
Target Antigen
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-78.html
Solubility
10 mM in DMSO
Smiles
BrC1=C(N[C@@H]2CCCN(S(C3CC3)(=O)=O)C2)N=C(NC4=CC=C(N5CCN(C)CC5)C=C4)N=C1
Molecular Weight
550.51
References & Citations
[1]Mao YZ, et al. Design, synthesis and evaluation of new pyrimidine derivatives as EGFRC797S tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2023 Jul 15;91:129381.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149889/EGFR-IN-78-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149889/
Clinical Information
No Development Reported
CAS Number
3042104-73-1
Available Sizes
Curated Selection
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