EGFR-IN-78
EGFR-IN-78 (compound A5), a 2-aminopyrimidine derivative, is a reversible inhibitor of EGFRC797S-TK, and also an inducer of apoptosis. EGFR-IN-78 shows anti-proliferative activity, inhibits EGFR phosphorylation and arrests cell cycle at G2/M phase[1].
Product Specifications
CAS Number
[3042104-73-1]
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-78.html
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
BrC1=C(N[C@@H]2CCCN(S(C3CC3)(=O)=O)C2)N=C(NC4=CC=C(N5CCN(C)CC5)C=C4)N=C1
Molecular Formula
C23H32BrN7O2S
Molecular Weight
550.51
References & Citations
[1]Mao YZ, et al. Design, synthesis and evaluation of new pyrimidine derivatives as EGFRC797S tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2023 Jul 15;91:129381.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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