Milrinone

Milrinone is a PDE3 inhibitor, and also an inotrope and vasodilator.

Product Specifications

CAS Number

[78415-72-2]

Product Name Alternative

Win 47203

UNSPSC

12352005

Hazard Statement

H317, H319

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Milrinone.html

Purity

99.86

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(N1)=C(C2=CC=NC=C2)C=C(C#N)C1=O

Molecular Formula

C12H9N3O

Molecular Weight

211.22

Precautions

H317, H319

References & Citations

[1]Santhosh KT, et al. Milrinone attenuates thromboxane receptor-mediated hyperresponsiveness in hypoxic pulmonary arterial myocytes. Br J Pharmacol. 2011 Jul;163 (6) :1223-36.|[2]Hentschel T, et al. Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure. Anesthesiology. 2007 Jan;106 (1) :124-31.|[3]Kishi T, et al. Effects of milrinone on left ventricular end-systolic pressure-volume relationship of rat hearts in situ. Clin Exp Pharmacol Physiol. 2001 Sep;28 (9) :737-42.|[4]Taylor MS, et al. Effect of milrinone on small mesenteric artery vasoconstriction: role of K (+) channels. Am J Physiol. 1999 Jul;277 (1 Pt 1) :G69-78.