ICI 169369 (free base)
ICI 169369 (free base) is an orally active, selective and non-competitive antagonist against 5HT receptor. ICI 169369 (free base) blunts the vasopressin (AVP), but not the ACTH, prolactin or growth hormone reponses to insulin-induced hypoglycaemia. ICI 169369 (free base) blocks centrally mediated 5-HT responses and lowers portal pressure in portal hypertensive rats[1][2][3][4].
Product Specifications
CAS Number
85273-95-6
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ici-169369-free-base.html
Smiles
CN(C)CCSC1=NC2=CC=CC=C2C=C1C3=CC=CC=C3
Molecular Formula
C19H20N2S
Molecular Weight
308.44
References & Citations
[1]Thompson CJ, et al. The effects of the specific serotonin antagonist ICI 169,369 on the pituitary hormone response to insulin-induced hypoglycaemia in humans. Clin Endocrinol (Oxf) . 1992 Mar;36 (3) :235-40.|[2]Blackburn TP, et al. In vitro studies with ICI 169,369, a chemically novel 5-HT antagonist. Eur J Pharmacol. 1988 Jun 10;150 (3) :247-56.|[3]Kaumann A J, et al. ICI 169,369 selectively blocks 5-hydroxytryptamine2 receptors and lowers portal pressure in portal hypertensive rats[J]. Gastroenterology, 1988, 95 (6) : 1601-1606.|[4]Blackburn TP, et al. Pharmacological studies in vivo with ICI 169,369, a chemically novel 5-HT2/5-HT1C receptor antagonist. Eur J Pharmacol. 1990 May 16;180 (2-3) :229-37.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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