Recombinant Human Interleukin-2 (rHuIL-2)

Interleukin 2 is a protein that has a variety of immunologic functions, the most notable being the ability of IL-2 to promote the proliferation and maturation of activated T cells. A comparison of the amino acid sequences of human and murine IL-2 shows an approximately 60% sequence similarity, and human sequence IL-2 has been found to be active on murine cell lines. Some of the biological activities attributed to IL-2 include: ● induction of secretion of interferon-γ and tumor necrosis factors -α and -β from peripheral blood mononuclear cells ● stimulation of the rate of synthesis of c-myc RNA and transferrin receptor ● activation of neutrophils ● stimulation of proliferation and maturation of activated helper T cells ● stimulation of proliferation of activated and natural killer cells and tumor-infiltrating lymphocytes, as well as enhancement of the ability of these cytotoxic lymphocytes to kill target cells ● induction of the expression of IL-2 receptors on T cells ● stimulation of proliferation of antibody-producing B cells