Recombinant Human Interleukin-13 Variant (rHuIL-13 variant)
The human IL-13 cDNA encodes a 132 amino acid protein containing a proposed 20 amino acid signal peptide. Human IL-13 shares approximately 30% amino acid sequence homology to human IL-4 and the two cytokines exhibit overlapping biological activities. Human IL-13 is produced by activated Th0, Th1-like Th2-like and CD8 T cells. Similarly to IL-4, IL-13 has multiple effects on the differentiation and functions of monocytes/macrophages. IL-13 can suppress the cytotoxic functions of monocytes/macrophages. It can also suppress the production of proinflammatory cytokines and upregulate the production of IL-1ra by monocytes/macrophages.
Product Specifications
Source
Escherichia coli.
Field of Research
Immunology & Inflammation
Endotoxin
Less than 1EU/g of rHuIL-13 variant as determined by LAL method.
Purity
>95% by SDS-PAGE and HPLC analyses.
Bioactivity
Form
Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.2, containing 5% trehalose.
Molecular Weight
Storage Conditions
Notes
For research use only.
Applications Notes
Preservative
Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.2, containing 5% trehalose.
AA Sequence
SPGPVPPSTA LRELIEELVN ITQNQKAPLC NGSMVWSINL TAGMYCAALE SLINVSGCSA IEKTQRMLSG FCPHKVSAGQ FSSLHVRDTK IEVAQFVKDL LLHLKKLFRE GQFN
Available Sizes
Frequently Asked Questions
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