Recombinant Human Interleukin-22 (rHu IL-22)
IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.
Product Specifications
Source
Escherichia coli.
Field of Research
Immunology & Inflammation
Endotoxin
Less than 1EU/mg of rHuIL-22 as determined by LAL method.
Purity
>97% by SDS-PAGE and HPLC analyses.
Bioactivity
Determined by its ability to activate STAT following receptor ligand interaction.
Form
Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 5.0.
Molecular Weight
Approximately 33.6 kDa, non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.
Storage Conditions
Notes
For research use only.
Applications Notes
Preservative
Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 5.0.
AA Sequence
Available Sizes
Frequently Asked Questions
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